Unlike most oral steroids, which are Class II steroids giving most of their anabolic effect by means other than the androgen receptor (AR), it seems that oxandrolone probably does have good binding to the AR, and is therefore a Class I steroid, while having little other effect. By itself it is considered to be a weak anabolic.
Partly this is due to its apparent lack of non-AR-mediated activity. This can be corrected of course by stacking with a Class II steroid such as dianabol, anadrol, 4-AD, or nor-4-AD: the latter two steroids require high blood levels which are not obtained by oral use of the powders.
The other part of the reason for this is that bodybuilders make unfortunate and unreasonable comparisons when judging anabolic steroids. If say 8 tablets per day does little, then the drug is pronounced useless or weak by the user. But that is only 20 mg/day, or 140 mg/week. Does 140 mg/week testosterone give much results? No. Few anabolic steroids give dramatic results at that dose. Per milligram the potency is reasonable, but each individual tablet is weak because the dosage is small.
Because of its high price, very few bodybuilders have taken large doses of oxandrolone. There is a single case in the medical literature (Forbes et al.) where it is reported that a competitive athlete self-administered 150 mg oxandrolone per day with remarkable gains. This is of uncertain credibility because unless urinalysis was done to verify that no other steroids were taken, there is no way to be certain that the athlete did not actually take more drugs than he reported. In any case, at current prices, only the quite wealthy could afford such a dose. I personally have tried 150 mg/day and considered it somewhat effective, but not dramatically so, and not a preferred regimen.
Oxandrolone does not aromatize or convert to DHT, and has a longer half life than Dianabol - 8 hours vs. 4 hours. Thus, a moderate dose taken in the morning is largely out of the system by night, yet supplies reasonable levels of androgen during the day and early evening.
Oxandrolone shares the liver toxicity problems common to 17-alkylated steroids. At one time it was thought that it did not, but both clinical and practical experience with Oxandrin has shown that at doses of 40 mg/day and higher, liver toxicity is indeed an issue with prolonged use.
Primobolan, I believe, should be considered a superior compound, offering the same activity at (usually) a lower price and without the alkylated-toxicity issue.
Effective Dose: 5 - 15 mg per day
Anavar, oxandrolone, tablets. Each Anavar tablet contains 2.5 mg. oxandrolone. Anavar, brand name Bonavar, comes in packs of 50 tablets and is manufactured by Body Research Ltd., Thailand.
Common uses and directions for Anavar, oxandrolone
Oxandrolone has often been used as a growth-promoting agent in the therapy of boys with growth delays in adolescence. Oxandrolone is also used in treating girls affected with Turner's syndrome, another growth-delay ailment. In obese individuals, oral oxandrolone has been shown to decrease subcutaneous abdominal fat more than Testosterone enanthate or weight loss alone, and it also tended to produce favorable changes in visceral fat.
Athletes like oxandrolone for three reasons. First, oxandrolone causes a strong strength gain by stimulating the phosphocreatine synthesis in the muscle cell without depositing water in the joints and the muscles.
Secondly, oxandrolone is one of the very few steroids that does not aromatize into estrogen, at any dosage, which has various advantages for the athlete.
The third reason for the popularity of Anavar is that oxandrolone does not influence the body's own testosterone production.
A suitable dosage of Anavar for a male athlete is 0.125 mg./pound of body weight per day. Women should not take more than about half of that dosage, though. Anavar is normally taken two to three times daily after meals thus assuring an optimal absorption of the oxandrolone.
Oxandrolone can give gastrointestinal problems ranging from a sensation of stomach fullness to appetite suppression, nausea, and diarrhea.
More information about Anavar (Oxandrolone):
Anavar (Oxandrolone) additional informationCommon uses
Oxandrolone is one of the few steroids, which does not cause an early stunting of growth in children since it does not prematurely close the epiphysial growth plates. For this reason oxandrolone is mostly used in children to stimulate growth and in women to prevent osteoporosis. In obese individuals, oral oxandrolone has been shown to decrease subcutaneous abdominal fat more than testosterone enanthate or weight loss alone, and it also tended to produce favorable changes in visceral fat.
Athletes like oxandrolone for three reasons. First, oxandrolone causes a strong strength gain by stimulating the phosphocreatine synthesis in the muscle cell without depositing water in the joints and the muscles.
Secondly, oxandrolone is one of the very few steroids that does not aromatize into estrogen, at any dosage, which has various advantages for the athlete.
The third reason for the popularity of Anavar is that oxandrolone does not influence the body's own testosterone production. This special feature of Anavar can be explained by the fact that the oxandrolone is not converted into estrogen.
Oxandrolone causes very light virilization symptoms, if at all. This characteristic makes Anavar a favored remedy for female athletes since, at a daily dose of 10-15 mg., masculinizing symptoms are observed only rarely.
DirectionsAnavar, brand name Bonavar, as a tablet, containing 2.5 mg. oxandrolone, to take by mouth.
Anavar should be taken two to three times daily after meals thus assuring an optimal absorption of the oxandrolone. Common dosage is 8-12 tablets in men and 5-6 tablets in women. The rule of thumb to take 0.125 mg./pound of body weight daily has proven successful in clinical tests.
Anavar can be combined with almost any other steroid such as Winstrol , Deca durabolin, Dianabol , or Anadrol .
If you miss a dose, take it as soon as remembered if it is within an hour or so. If you do not remember until later, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
PrecautionsWomen should not take more than 15 mg. daily otherwise, androgenic-caused side effects such as acne, deep voice, clitorial hypertrophy or increased growth of body hair can occur.
Since oxandrolone is only slightly toxic and usually shows few side effects, several athletes use it over a prolonged period of time. However Anavar should not be taken for several consecutive months, since, as with almost all oral steroids it is 1 7-alpha alkylated and thus liver toxic.
Possible side effects
Oxandrolone can give gastrointestinal problems ranging from a sensation of stomach fullness to appetite suppression, nausea, and diarrhea. The symptoms can be reduced by taking the tablets one-two hours after the meals.
Oxandrolone has negative effects on blood lipids.
In females, dosages above 15 mg./day can cause facial hair, deepening of the voice, clitoral hypertrophy, and acne.
If you notice other effects not listed above, contact your doctor.>
If overdose of anavar is suspected, contact your local poison control center or emergency room immediately.
Keep oxandrolone in a tightly closed container and out of reach of children. Store oxandrolone at room temperature and away from excess heat and moisture (not in the bathroom).
The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, or other healthcare professional. It should not be construed to indicate that use of oxandrolone is safe, appropriate, or effective for you. Consult your healthcare professional before using anavar.
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Anavar was the old U.S. brand name for the oral steroid oxandrolone, first produced in 1964 by the drug manufacturer Searle. It was designed as an extremely mild anabolic, one that could even be safely used as a growth stimulant in children. One immediately thinks of the standard worry, "steroids will stunt growth". But it is actually the excess estrogen produced by most steroids that is the culprit, just as it is the reason why women stop growing sooner and have a shorter average stature than men. Oxandrolone will not aromatize, and therefore the anabolic effect of the compound can actually promote linear growth. Women usually tolerate this drug well at low doses, and at one time it was prescribed for the treatment of osteoporosis. As the opinions surrounding steroids began to change in the 1980's, prescriptions for oxandrolone began to drop. Lagging sales probably led Searle to discontinue manufacture in 1989, and it had vanished from U.S. pharmacies until recently. Oxandrolone tablets are again available inside the U.S. by BTG, bearing the new brand name Oxandrin. BTG purchased rights to the drug from Searle and it is now manufactured for the new purpose of treating HIV/AIDS related wasting syndrome.
Anavar is a mild anabolic with low androgenic activity. Its reduced androgenic activity is due to the fact that it is a derivative of dihydrotestosterone (DHT). Although one might think that this would make it a more androgenic steroid, it in fact creates a steroid that is less androgenic because it is already "5-alpha reduced". In other words, it lacks the capacity to interact with the 5-alpha reductase enzyme and convert to a more potent "dihydro° form. It is a simple matter of where a steroid is capable of being potentiated in the body, and with oxandrolone we do not have the same potential as testosterone, which is several times more active in androgen responsive tissues compared to muscle tissue due to its conversion to DHT. It essence oxandrolone has a balanced level of potency in both muscle and androgenic target tissues such as the scalp, skin and prostate. This is a similar situation as is noted with Primobolan and Winstrol, which are also derived from dihydrotestosterone yet not known to be very androgenic substances.
This steroid works well for the promotion of strength and duality muscle mass gains, although it's mild nature makes it less than ideal for bulking purposes. Among bodybuilders it is most commonly used during cutting phases of training when water retention is a concern. The standard dosage for men is in the range of 20-50mg per day, a level that should produce noticeable results. It can be further combined with anabolics like Primobolan and Winstrol to elicit a harder, more defined look without added water retention. Such combinations are very popular and can dramatically enhance the show physique. One can also add strong non-aromatizing androgens like Halotestin, Proviron or trenbolone. In this case the androgen really helps to harden up the muscles, while at the same time making conditions more favorable for fat reduction. Some athletes do choose to incorporate oxandrolone into bulking stacks, but usually with standard bulking drugs like testosterone or Dianabol. The usual goal in this instance is an additional gain of strength, as well as more quality look to the androgen bulk. Women who fear the masculinizing effects of many steroids would be quite comfortable using this drug, as this is very rarely seen with low doses. Here a daily dosage of 5mg should illicit considerable growth without the noticeable androgenic side effects of other drugs. Eager females may wish to addition mild anabolics like Winstrol, Primobolan or Durabolin. When combined with such anabolics, the user should notice faster, more pronounced muscle-building effects, but may also increase the likelihood of androgenic buildup.
Studies using low dosages of this compound note minimal interferences with natural testosterone production. Likewise when it is used alone in small amounts there is typically no need for ancillary drugs like Clomid/Nolvadex or HCG. This has a lot to do with the fact that it does not convert to estrogen, which we know has an extremely profound effect on endogenous hormone production. Without estrogen to trigger negative feedback, we seem to note a higher threshold before inhibition is noted. But at higher dosages of course, a suppression of natural testosterone levels will still occur with this drug as with any anabolic/androgenic steroid and therefore require post cycle therapy to restore the HPTA.
Anavar is also a 17alpha alkylated oral steroid, carrying an alteration that will put stress on the liver. It is important to point out however that dispite this alteration oxandrolone is generally very well tolerated. While liver enzyme tests will occasionally show elevated values, actual damage due to this steroid is not usually a problem. Bio-Technology General states that oxandrolone is not as extensively metabolized by the liver as other l7aa orals are; evidenced by the fact that nearly a third of the compound is still intact when excreted in the urine. This may have to do with the understood milder nature of this agent (compared to other l7aa orals) in terms of hepatotoxicity. One study comparing the effects of oxandrolone to other agents including as methyltestosterone, norethandrolone, fluoxymesterone and methAndriol clearly supports this notion. Here it was demonstrated that oxandrolone causes the lowest sulfobromophthalein (BSP; a marker of liver stress) retention among all the alkylated orals tested. 20mg of oxandrolone in fact produced 72% less BSP retention than an equal dosage of fluoxyrnesterone, which is a considerable difference being that they possess the same liver-toxic alteration. With such findings, combined with the fact that athletes rarely report trouble with this drug, most feel comfortable believing it to be much safer to use during longer cycles than most of other orals with this distinction. Although this may very well be true, the chance of liver damage still cannot be excluded, especially with hogher dosages.
At one time oxandrolone was also looked at as a possible drug for those suffering from disorders of high cholesterol or triglycerides. Early studies showed it to be capable of lowering total cholesterol and triglyceride values in certain types of hyperlipidemic patients, which initially this was thought to signify potential for this drug as a hypo-lipid (lipid lowering) agent. With further investigation we find however that while use of this drug can be linked to a lowering of total cholesterol values, it is such that a redistribution in the ratio of good (HDL) to bad (LDL) cholesterol occurs, usually moving values in an unfavorable direction. This would of course negate any positive effect that the drug might have on triglycerides or total cholesterol, and in fact make it a danger in terms of cardiac risk when taken for prolonged periods of time. Today we understand that as a group anabolic/androgenic steroids produce very unfavorable changes in lipid profiles, and are really not useful in disorders of lipid metabolism. As an oral c17 alpha alkylated steroid, oxandrolone is probably even more risky to use than an injectable esterified injectable such as a testosterone or nandrolone in this regard.
Alternative Description Anavar® / Oxandrolone® / Oxandrin® 5mg x 30 tablets:
Anavar was developed to treat conditions of muscle wasting and rapid weight loss, as is a common reason for inception with any anabolic steroid. Developed in 1964, by Searle Laboratories to treat such conditions, Searle is no longer in existence as it was bought and absorbed into Pfizer in 2003. However, it was Searle’s development of Anavar that is of importance because this is a pharmacy that has brought us some of the most well-known medications and other items we still use today, most notably, Celebrex, Ambien, Dramamine and NutraSweet. As you can see Searle developed some very important products over the years and its development of Anavar is no exception because with its inception one of the safest anabolic steroids for both men and women would hit the shelves.
Comprised of Oxandrolone, Anavar as it is commonly known is a Dihydrotestosterone (DHT) anabolic steroid with almost no androgenic qualities and mild anabolic properties. An oral steroid, Anavar is like most oral steroids a C17alpha-alkylated medication (17-aa) meaning it has been altered at the 17th carbon position to allow it to survive ingestion by surviving the first pass through the liver; without the 17-aa alteration the steroid would be destroyed before it ever entered the blood stream. By this alteration the steroid is allowed to survive and enter the blood stream where it becomes active and the benefits are received. As you may understand the 17-aa process can be toxic to the liver, for this reason many individuals will avoid oral anabolic steroids but as it pertains to Anavar we must make an exception. Unlike most 17-aa medications Anavar appears to be very mild on the liver, so mild that most who use it experience little to no elevation in liver enzymes.
Once in the blood Anavar becomes active very quickly, as is common with most oral steroids, especially those of a DHT nature. Further, this rapid activity time is largely due to its very short half-life which is approximately 9 hours. Because the half-life of Anavar is so short daily administration of the medication is necessarily frequent with twice daily ingestion of the medication being optimal. You could easily administer the medication only once per day and still receive the benefits of Anavar, however, if we are to keep blood levels stable twice per day will be more efficient as once per day administration would result in very little of the medication still being active in the body once a 24 hour period has passed. Granted, for lower end doses, especially for females once per day will prove to be sufficient.
The Benefits of Anavar
As a very mild anabolic steroid Anavar is not well-suited for bulking cycles or gaining phases; you will not produce a vast amount of lean muscle tissue through its use when speaking of performance enhancing purposes; however, what is produced will be solid muscle tissue. The greatest benefits associated with this particular steroid lie within muscle preservation and metabolic activity. This simply means Anavar has the ability to not only aid in reducing body-fat but preserving muscle tissue while on a calorie restricted diet; further, the more muscle tissue we have the greater our metabolic activity will be thereby increasing the rate in-which body-fat is utilized for energy. Because Anavar is apt for fat reduction and muscle preservation it is commonly used by physique athletes during their competition preparation, as well as by common gym rats who simply want to look leaner and tighter at the beach.
The Side-Effects of Anavar
Most anabolic steroids carry with them the possibility of many adverse side-effects. It is important to keep in mind these side-effects are only possible, they are by no means guaranteed or assured and are largely avoidable when used responsibly. However, negative side-effects can occur when steroids are abused and even in some who are sensitive even though they use responsibly they may fall prey to negative outcomes; the same can be said of Aspirin. While many anabolic steroids carry vast possible negative side-effects such as estrogenic related due to aromatization, Anavar does not possess these traits. Anavar does not aromatize making common side-effects such as Gynecomastia little to no concern; Further, as most steroids are very suppressive to natural testosterone production Anavar is very mild in this regard, so mild that one could take Anavar and still produce some natural testosterone. However, some suppression will still exist and the extent will largely be dose dependent.
Anavar & Women
Anabolic steroids can be very damaging to women as they can often cause masculine effects due to virilization, such as deepened vocal chords, body-hair growth and clitoral enlargement. However, due to its mild nature Anavar appears to be virtually side-effect free not only for men but for women as well, making it the ultimate anabolic steroid for any female user. While this steroid can be used successfully by both men and women, because it is so female friendly many refer to Anavar as “The Girl Steroid.”
Anavar Cycles & Doses
Most men who use Anavar will necessarily need to use a large amount to receive any noticeable benefit as this steroid’s extremely mild nature will require it. Most men will find 50mg per day to be the minimum dose if they expect to see any positive and noticeable results with 80mg per day being far more common. Conversely, as women are more sensitive to anabolic steroids lower doses need to be applied; further, lower doses absolutely ensure side-effects will remain non-existent. Most women will find 10mg per day to be nearly perfect with 20mg per day being the maximum amount of Anavar most will ever want or need to use.
Regardless of who uses it, men or women, Anavar can successfully be used for longer periods of time than most oral anabolic steroids, however, 6-8 weeks of use is common place. For most it will not matter at which point of a steroid cycle you include Anavar, however, if you are trying to lean out, to get the most bang for your buck the steroid will be best served towards the end of a cycle, as its benefits will be far greater and pronounced the leaner you already are.
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