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Provironum┬® is the Schering brand name for the oral androgen mesterolone (1 methyl-dihydrotestosterone). Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. In clinical situations Provironum┬® is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count. The drug does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen.
Although this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes. This is due to the fact that Provironum┬® is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone, The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously. In fact due to its extremely high affinity for plasma binding proteins such as SHBG, Provironum┬® may actually work to potentate the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes Provironum┬® is primarily used as an antiestrogen. It is believed to act as an antiaromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to Arimidex┬® (though less profound), the drug acting to prevent the buildup of estrogen in the body. This is in contrast to Nolvadex┬®, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. A related disadvantage to Nolvadex┬® is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia and water retention. Most athletes actually prefer to use both Provironum┬® and Nolvadex┬®, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly minimized.
The anti-estrogenic properties of Provironum┬® are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron (2methyl-dihydrotestosterone) for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect. It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization seems to be the liver). The antiestrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet being unable to alter it, and inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones.
This drug is also favored by many during contest preparations, when a lower estrogen/high androgen level is particularly sought after. This is especially beneficial when anabolics like Winstrol┬®, oxandrolone and Primobolan┬® are being used alone, as the androgenic content of these drugs is relatively low. Provironum┬® can supplement a wellneeded androgen, and bring about an increase in the hardness and density of the muscles. Women in particular find a single 25mg tablet will efficiently shift the androgen/estrogen ratio, and can have a great impact on the physique. Since this is such a strong androgen however, extreme caution should be taken with administration. Higher dosages clearly have the potential to cause virilization symptoms quite readily. For this reason females will rarely take more than one tablet per day, and limit the length of intake to no longer than four or five weeks. One tablet used in conjunction with 10 or 20mg of Nolvadex┬® can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat (especially in female trouble areas like the hips and thighs).
The typical dosage for men is one to four 25 mg per tablets per day. This is a sufficient amount to prevent gynecomastia, the drug often used throughout the duration of a strong cycle. As mentioned earlier, it is often combined with Nolvadex┬® (tamoxifen citrate) or Clomid┬® (clomiphene citrate) when heavily estrogenic steroids are being taken (Dianabol, testosterone etc.). Administering 50mg of Provironum┬® and 20mg Nolvadex┬® daily has proven extremely effective in such instances, and it is quite uncommon for higher dosages to be required. And just as we discussed for women, the androgenic nature of this compound is greatly welcome during contest preparation. Here again Provironum┬® should noticeably benefit the hardness and density of the muscle, while at the same time increasing the tendency to burn off a greater amount of body fat. Provironum┬® is usually well tolerated and side effects (men) are rare with dosages under 100 mg per day. Above this, one may develop an excessively high androgen level and encounter some problems. Typical androgenic side effects include oily skin, acne, body/facial hair growth and exacerbation of a male pattern baldness condition, and may occur even with the use of a moderate dosage. With the strong effect DHT has on the reproductive system, androgenic actions may also include an extreme heightening of male libido. And as discussed earlier, Women should be careful around Provironum┬®. It is an androgen, and as such has the potential to produce virilization symptoms quite readily. This includes, of course, a deepening of the voice, menstrual irregularities, changes in skin texture and clitoral enlargement.
Provironum┬® is also not a c17 alpha alkylated compound, an alteration commonly used with oral anabolic/androgenic steroids. Not using this structure in the case of Provironum┬® removes the notable risk of liver toxicity we normally associate with oral dosing. We therefore consider this a "safe" oral, the user having no need to worry about serious complications with use. This steroid in fact utilizes the same 1-methylation we see present on Primobolan┬® (methenolone), another well tolerated orally active compound. Alkylation at the one position also slows metabolism of the steroid during the first pass, although much less profoundly than 17 alpha alkylation. Likewise Provironum┬® and Primobolan┬® are resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability of these compounds is still much lower than methylated oral steroids.
The popularity of Provironum┬® amongst bodybuilders has been increasing in recent years. Many experienced bodybuilders have in fact come to swear by it, incorporating it effectively in most markedly estrogenic cycles. Due to high demand Provironum┬® is now very easy to obtain on the black market. Most versions will be manufactured by Schering. In many instances this item is obtained via mail order, and here can sell for less than .50 per tab. This drug is packaged in both push-through strips and small glass vials, so do not let this alarm you. There is currently no need to worry about authenticity with this drug, as no counterfeits are known to exist. If money and availability does not prevent it, Arimidex┬® is actually a much better choice than Provironum┬® though. This drug was designed specifically as an antiaromatase, and works much more effectively than anything else we have available. Since this item is extremely expensive however, Nolvadex┬® and Provironum┬® will no doubt remain to be the "standard" antiestrogen regimen among athletes.
Proviron is the brand name for the orally applicable androgen and DHT (dihydrotestosterone) derivative called Mesterolone. Roughly 5% of testosterone undergoes 5-alpha reduction to form the potent androgen DHT, which is a sex hormone and androgen hormone. DHT plays a major role in the formation of the male genitals, and, in adults, it acts as the primary androgen in the prostate and hair follicles. Proviron is almost as pure a DHT steroid as you will find out there. With DHT compounds such as proviron, you need not worry about any estrogen aromatization.
Studies have shown proviron is effective for depression, anxiety and to boost lack of sex drive. Hence, it would make sense that those with bipolar, unipolar, and dysthymia would benefit from this hormone. It’s generally prescribed by doctors to men with low libido. In addition, it’s a precursor to full TRT (testosterone replacement therapy).
Proviron was popularized years ago as an anti-estrogen because it is has a high affinity to bind to the aromatase enzyme, so anabolic steroid (AS) users could use it to serve as their AI (aromatase inhibitor) replacement. Bodybuilders were using it during post cycle therapy (PCT); unfortunately, studies have shown proviron does suppress LH (luteinizing hormone) — in some cases. As a result, high proviron dosage can prevent the pituitary gland from recovering after a steroid cycle. Some users insist proviron does not suppress the HPTA when used in PCT or during a bridge; however, this is up for debate. As a side note, some studies support long term use of proviron at high dosages without serious suppression. The science supports proviron use for PCT but not in every case.
Now that we have aromasin, arimidex, and letrozole, proviron has become obsolete when it comes to anti-estrogen usage. We know that the true aromatase inhibitors (AI) are safe to use during post cycle therapy, and will not suppress your HPTA. Though, proviron shouldn’t either.
In this respect, it doesn’t mean proviron does not have its uses on cycle when using an aromatizing compound such as dianabol, testosterone, nandrolones, or equipoise. In fact, a user can expect to have a harder look, more vascularity, and less puffiness when stacking proviron with a wet compound.
Another benefit of proviron is that it binds very well to SHBG (sex hormone binding globulin), which is the hormone responsible for reducing free testosterone circulating in the body. This is probably the reason why some use proviron during PCT.
Those that compete will appreciate proviron’s hardening properties. Since proviron is 5-alpha reduced and not capable of forming estrogen, it will help give a drier look.
Since it has no anabolic properties, proviron is worthless when used alone by a bodybuilder. However, when stacked, it can turn a wet compound into a perfect balance of size and hardness for your muscles. My favorite oral stack is dianabol and proviron at 25mgs each per day. I did not get the normal bloated and puffy muscle look from dbol alone as the proviron helped balance it out. Since proviron is a non c17 alpha-alkylated compound, it is safe to stack with an oral.
Proviron can be stacked with any anabolic steroid safely. In fact, it’s been called oral masteron by many, and rightfully so.
Sample Proviron Cycle:
Since proviron is such a pure DHT derivative, we can logically say that it comes with sides, just like any other anabolic steroid. However, the side effects come from its DHT characteristics, so you can expect male pattern baldness issues, especially if you are prone to it. This is why those that choose DHT compounds and suffer from hair issues will run a 5alpha reductase inhibitor such as finasteride, or dutasteride, to counteract this side effect. DHT’s can also enlarge the prostate, but this is generally only in those that abuse them. As mentioned above, proviron is not a c17 alpha-alkylated compound, so liver problems are not an issue with it.
The half life of proviron is around 12 hours. A good recommended dosage is 25-75mg per day; though, I have personally never exceeded 50mg a day in a stack. The detection time is 5-6 weeks. so those that are tested often would be wise to avoid this compound. Females are not advised to take proviron because of its DHT properties. Side effects for females can be very nasty and unpredictable.