Breast cancer is one of the curses of the 20th century. Unfortunately, more and more women are suffering from breast cancer and thorough research is conducted in order to find a cure. Unfortunately, sometimes the breast cancer will spread to other areas of the body and further medication is need: this is where Nolvadex comes into the picture.
Nolvadex is used for its effects not only for breast cancer
Nolvadex is a medicine used to treat breast cancer that has already spread to other areas of the body. Nolvadex is efficient not only for breast cancer itself. Because of its effects, it is used for many of breast cancer types and also used for women with high risk of breast cancer or women with DCIS after their surgery and radiation.
Great precaution for Nolvadex to produce its effects on breast cancer
How does Nolvadex work? This is a medicine part of the antiestrogen category. It will block the effect that estrogen has on different tumors, by preventing their growth. The right dosage of Nolvadex should be established with your doctor for the right effects. All the instructions should be followed thoroughly in order for Nolvadex to create its effects on the breast cancer or any other issues it was prescribed for.
The side effects of Nolvadex
Nolvadex also comes with side effects. While it is efficient in fighting against breast cancer, this medicine comes with some negative effects and these should be known so you wouldn’t be taken by surprise. Firstly, women taking Nolvadex for breast cancer have experienced side effects such as dizziness, irregular periods, bone and tumor pain – but these effects usually mean that the drug is fighting efficiently against breast cancer.
Nolvadex , great effects for men with breast cancer
In some cases, hot flashes can be included on the list of side effects of Nolvadex . Very rarely, women with breast cancer taking Nolvadex have experienced hair loss, vaginal dryness, depression, headaches and distaste for food. Besides these side effects, one should note the fact that Nolvadex has been successfully used to treat breast cancer also in men. Its effects make it a good choice when thinking about which treatment to buy.
Nolvadex has no effect on pregnancy, even with breast cancer
You might be worrying about the effects that Nolvadex might have in case of a pregnancy since it is an antiestrogen. This medicine will not prevent women from becoming pregnant and can be taken under the supervision of the doctor during the pregnancy. On the other hand, a nasty side effect of Nolvadex while taking it for breast cancer is the fact that it diminishes the body’s ability to fight infections and reduces the number of clot-forming cells. These are two important effects that should be taken in consideration when choosing Nolvadex as a solution for breast cancer.
Nolvadex is a good choice when it comes to the treatment of breast cancer. Although it has some side effects, overall the positive effects make it an efficient weapon against breast cancer and this should be born in mind when buying the right treatment.
This article presents the benefits of using Nolvadex for the treatment of breast cancer, also pointing out the side effects.
Description Nolva (Tamoxifen Citrate) 20mg 30tabs Geneza Pharmaceuticals:
Tamoxifen is antiestrogen, produced for the reason of breast cancer in women because of high estrogenic amounts in there adipose tissues. For male athletes it was used for the primarily reason to stop the effect of conversion into estrogen causing gynecomastia. The structure of estrogen is very similar to testosterone, since it can aromatize many anabolic steroids is why the buildup of estrogens can be very serious concern. Estrogen can do two things negatively in males one is the extra build of fat, secondly being the extra water retention buildup in the body.Also it can increase production of FSH (follicle stimulating hormone) and LH (leutinizing hormone) in the male body. Activating the estrogen receptor can have a positive effect on HDL (good) cholesterol values.
Dosage Nolva (Tamoxifen Citrate) 20mg 30tabs Geneza Pharmaceuticals: Usual range with this drug would be 10 to 30mg a day and a duration of time which would be the amount needed on a individual basis of the problem to be resolved and back to normal.
Used in high amounts can cause an adverse effect complicating matters and the gains of the cycle could diminish slightly
Tanoxifen(Tamoxifen)Just read an article in my local Sacramento CA Newspaper Titled "Study:Tamoxifen's Effectiveness Fades."
"Tamoxifen. a drug that fights breast cancer by blocking the action of the hormone estrogen. eventually loses its effectiveness and then actually may help the cancer grow, researchers say.'
"In a study to be published today in the journal Science. scientists at Duke University Medical Center said they have found that the reaction of breast cells to tanoxifen changes over time until the drug starts to behave like the hormone it is supposed to block."
"Over time , the drug causes the estrogen receptor on cells to change and form a pocketlike structure that allows other proteins to bind there. The proteins action somehow changes the cell's reaction to Tamoxifen. Theres more to the article but this is the essence of it. Probably you will find something in your papers as it from the Associated Press Newswire. But just in case - thought you should be made aware.
Active Life: 5-7 days
Drug Class: Selective Estrogen Receptor Modulator (Oral)
Average Dose: 10-30 mg/day
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: low
Tamoxifen Citrateis a non-steroidal agent that demonstrates potent anti-estrogenic properties. The drug is technically an estrogen agonist/antagonist, which competitively binds to estrogen receptors in various target tissues. With the tamoxifen molecule bound to this receptor, estrogen is blocked from exerting any action, and an anti-estrogenic effect is achieved. Since many forms of breast cancer are responsive to estrogen, the ability of tamoxifen citrate to block its action in such cells has proven to be a very effective treatment. It is also utilized successfully as a preventative measure, taken by people with an extremely high familial tendency for breast cancer. While Nolvadex is effective against estrogen, it is not our strongest available remedy. We now have the drugs Arimidex, Femara, and Aromasin available to us, which notably prevents estrogen from being manufactured in the first place. Altering the effect of estrogen in the female body can cause a level of discomfort, so anti-estrogens are most bearable when used after the point of menopause. Since Nolvadex is milder in comparison, it is more widely applicable and usually the first treatment option.
As discussed earlier, an enzyme in the male body (aromatase) is capable of altering testosterone to form estradiol. The structure of estrogen is actually quite similar to testosterone, so its presence in the male body is not all that remarkable. Since this same enzyme can also aromatize many anabolic/androgenic steroids, the buildup of estrogens can be an important concern during intake. High levels can cause a number of unwanted side effects, a primary worry being gynecomastia or the development of female breast tissue in men. This can be first noticed by the appearance of swelling or a small lump under the nipple. If left to progress it can turn into a very unsightly development of tissue, often irreversible without surgery. Estrogen can also lead to an increase in the level of water retained in the body. The result here can be a notable loss of definition, the muscles beginning to look smooth and bloated due to the retention of subcutaneous fluid. Fat storage may also be increased as estrogen levels rise. This hormone is in fact the primary reason women have a higher body fat percentage, and different fat distribution (hips/thighs) than men. Individuals sensitive to the effects of estrogen will usually be sure to have an anti-estrogen on hand when taking problematic steroids, so as to minimize the impact of related side effects.
This drug also shows the ability to increase production of FSH (follicle stimulating hormone) and LH (luteinizing hormone) in the male body. This is accomplished by blocking negative feedback inhibition caused by estrogen at the hypothalamus and pituitary, which fosters the release of the mentioned pituitary hormones. This of course is also the function of Clomid and cyclofenil. Since a higher release of LH can stimulate the Leydig's cells in the testes to produce more testosterone, Nolvadex can have a positive impact on one's serum testosterone level. This "testosterone stimulating" effect is an added benefit when preparing to conclude a steroid cycle (post cycle therapy or PCT). Since most anabolic/androgenic steroids will suppress endogenous testosterone production, Nolvadex can help restore a balance in hormone levels. Nolvadex should be preferred over Clomid for this purpose in fact, as side by side it is clearly the stronger agent. It has also been shown to increase LH responsiveness to Gonadotropin Releasing Hormone after time, while Clomid slightly lowers this sensitivity as the drug is used for several weeks..
In some cases the use of only an estrogen antagonists such as Nolvadex or Clomid may be sufficient for testosterone stimulating purposes, particularly when halting the use of a milder or shorter steroid program (which should have a less pronounced impact on the hormonal system). With stronger cycles most option to enhance the stimulating effect of these drugs with HCG, a hormone that mimics the action of LH. HCG use provides an excessive level of stimulation to the testes, which in essence may shock them out of a prolonged state of inactivity. In such a condition the Leydig's cells may not be producing a normal amount of testosterone, even though the normal release of gonadotropins has been achieved. Nolvadex can be tricky at this point. Remember it only blocks the effect of estrogen that is present in the body. If it is removed at a time when estrogen levels are still unusually high, related side effects can quickly become a pronounced problem. Since HCG not only increases the production of testosterone but also enhances the rate of aromatization in the testes, anti-estrogens should not be discontinued until at least a couple of weeks after HCG is discontinued. The result otherwise of course could be many unwanted side effects that were previously under control. When using Nolvadex to ward off the effects of estrogen during the cycle, it should similarly not be removed until the user is confident that hormone levels are well under control. With a drug such as Sustanon, this may mean continuing it for several weeks after the last shot.
A typical daily dosage for men is in the range of 10 to 30mg, the amount would be dependent on the level of effect desired. It is advisable to begin with a low dosage and work up, to avoid taking an unnecessary amount. The time in which Nolvadex is started also relies on individual needs of the user. If an athlete with a known sensitivity to estrogen is starting a strong steroid cycle, Nolvadex should probably be added soon after the cycle had been initiated. If estrogen is probably not going to be a major problem during the cycle (but will likely be after), Nolvadex is administered around the time exogenous steroid levels will drop. It will be continued for some weeks after, until the point when natural testosterone is thought to be at an acceptable level. As mentioned HCG is often used at this point as well (see related profile for more detail). Women have also utilized Nolvadex in an effort to reduce the effect of their own endogenous estrogens. This can lower body fat concentrations, especially in stubborn areas like the hips and thighs. This is of course risky, as manipulating the effect of estrogen can become uncomfortable in women. Side effects like hot flashes, menstrual irregularities and a variety of complications with the reproductive system are all possible.
When looking for a stronger anti-estrogenic effect, Proviron can make a good addition to Nolvadex. Although this compound is technically an androgen, it may have a pronounced effect on the production of estrogen in the body. Its mode of action is therefore very different than that of Nolvadex. While Nolvadex only blocks the binding ability of free-floating estrogen, Proviron can minimize the creation of it. With each drug attacking estrogen via a different mechanism, we have a very synergistic combination. A daily intake of 20-30mg Nolvadex and 25-50mg Proviron can be extremely effective when dealing with a strong estrogenic cycle. Women often avoid adding Proviron to Nolvadex treatment (thought often it is still used to enhance fat loss), for fear of developing virilization symptoms (Proviron is an oral DHT). Virilizing effects can occur very quickly once there has been a dramatic rise in the activity of androgens (intensified by a decrease in estrogen activity), so at a minimum women should be careful with such a combination.
Of great interest also is that Nolvadex is an estrogen agonist in the liver, capable of activating the estrogen receptor and mimicking the actions of this sex hormone in this region of the body. As such it can have a markedly positive impact on HDL (good) cholesterol values, as does estrogen. Many similarly use this drug to counter some of the negative consequences of steroid use in regards to cholesterol values and cardiac risk, as steroids often suppress HDL and raise LDL levels considerably. in some instances an athlete is able to maintain a very favorable HDL/LDL cholesterol ratio, to spite the use of a moderate dosage (400mg weekly) of an injectable like testosterone or nandrolone. It would be foolish to think however that Nolvadex would be a sufficient remedy with the heavy use of c-l7alpha alkylated orals or extremely high dosed cycles in general.
It has been reported by many however that Nolvadex seems to slightly reduce to gains made during a steroid cycle. It appears that many androgenic/anabolic steroids will exhibit their most powerful anabolic effect when accompanied by a sufficient level of estrogen. This may be one reason why gains made with a strong androgen like testosterone are usually much more pronounced than when using an anabolic that aromatizes to a lower degree. It therefore seems like good advice to be aware of how much Nolvadex is actually needed before committing to it during a cycle. Many people in fact find it unnecessary, even when utilizing problematic compounds such as testosterone or Dianabol. Others however find they are troubled by water retention and gynecomastia, even with milder anabolics like Deca-Durabolin and Equipoise. The estrogenic response to steroid use is very individual, and may be influenced by factors such as age and body fat percentage (adipose tissue is a primary site of aromatization).
Nolvadex is certainly the most popular anti-estrogen used by athletes today, no doubt because it is simply an effective product. It is also widely manufactured, and easy to obtain. Since there never seems to be a lack of supply, there is little incentive to manufacture a counterfeit product. All of the various generics forms of this drug are no doubt trustworthy. Women should remember to be very cautious when considering the use of Nolvadex, as they are usually very sensitive to changes in the activity of estrogen. Men looking for a stronger anti-estrogenic effect may want to consider using Arimidex, Femara, or Aromasin , three powerful new anti-aromatase compounds. They are much more effective for estrogen control.
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