Anapolon 50mg / Anadrol 50mg® (Oxymetholone)
Anadrol 50® is the U.S. brand name for oxymetholone, a very potent oral androgen. This compound was first made available in 1960, by the international drug firm Syntex. Since oxymetholone is quite reliable in its ability to increase red blood cell production (and effect admittedly characteristic of nearly all anabolic/androgenic steroids), it showed particular promise in treating cases of severe anemia. For this purpose it turned out to be well suited, and was popular for quite some time. But recent years have brought fourth a number of new treatments, most notably the non-steroidal hormone Epogen (erythropoietin). This item is shown to have a much more direct effect on the red blood cell count, without the side effects of a strong androgen. Financial disinterest finally prompted Syntex to halt production of the U.S. Anadrol 50® in 1993, which was around the same time they decided to drop this item in a number of foreign countries. Plenastril from Switzerland and Austria was dropped; following soon was Oxitosona from Spain. Many Athletes feared Anadrol 50C~ might be on the way out for good. But new HIV/AIDS studies have shown a new light on oxymetholone. These studies are finding (big surprise) exceptional anti-wasting properties to the compound and believe it can be used safely in many such cases. Interest has been peaked, and as of 1998 Anadrol 50® is again being sold in the United States. This time we see the same Anadrol 50® brand name, but the manufacturer is the drug firm Unimed. Syntex continues to market & license this drug in a number of countries however (under a few different brand names).
Anadrol 50® is considered by many to be the most powerful steroid available, with results of this compound being extremely dramatic. A steroid novice experimenting with oxymetholone is likely to gain 20 to 30 pounds of massive bulk, and it can often be accomplished in less than 6 weeks, with only one or two tablets per day. This steroid produces a lot of trouble with water retention, so let there be little doubt that much of this gain is simply bloat. But for the user this is often little consequence, feeling bigger and stronger on Anadrol 50 ® than any steroid they are likely to cross. Although the smooth look that results from water retention is often not attractive, it can aid quite a bit to the level of size and strength gained. The muscle is fuller, will contract better and is provided a level of protection in the form of "lubrication" to the joints as some of this extra water is held into and around connective tissues. This will allow for more elasticity, and will hopefully decrease the chance for injury when lifting heavy. It should be noted however, that on the other hand the very rapid gain in mass might place too much stress on your connective tissues for this to compensate. The tearing of pectoral and biceps tissue is commonly associated with heavy lifting while massing up on heavy androgens. There is such a thing as gaining too fast. Pronounced estrogen trouble also puts the user at risk for developing gynecomastia. Individuals sensitive to the effects of estrogen, or looking to retain a more quality look, will therefore often add Nolvadex ® to each cycle.
It is important to note however, that this drug does not directly convert to estrogen in the body. Oxymetholone is a derivative of dihydrotestosterone, which gives it a structure that cannot be aromatized. As such, many have speculated as to what makes this hormone so troublesome in terms of estrogenic side effects. Some have suggested that it has progestational activity, similar to nandrolone, and is not actually estrogenic at all. Since the obvious side effects of both estrogens and progestins are very similar, this explanation might be a plausible one. However we do find medical studies looking at this possibility. One such tested the progestational activity of various steroids including nandrolone, norethandrolone, methandrostenolone, testosterone and oxymetholone 3. It reported no significant progestational effect inherent in oxymetholone or methandrostenolone, slight activity with testosterone and strong progestational effect inherent in nandrolone and norethandrolone. With such findings it starts to seem much more likely that oxymetholone can intrinsically activate the estrogen receptor itself, similar to but more profoundly than the estrogenic androgen meth Andriol. In speaking with chemist Patrick Arnold about my thoughts on this, I was afforded very believable support for my suspected explanation.
"I share your thoughts on this. Anadrol has an acidic hydrogen in the A-ring at a vicinity that is approximate to where the acidic phenolic hydrogen of estradiol is. I suspect it is a potent estrogen agonist'
Clearly if this is the case we can only combat the estrogenic side effects of oxymetholone with estrogen receptor antagonists such as Nolvadex® or Clomid®, and not with an aromatase inhibitor. The strong anti-aromatase compounds such as Cytadren and Arimidex ® would similarly prove to be totally useless with this steroid, as aromatase is uninvolved.
Anadrol 50 ® is also a very potent androgen. This trait tends to produce many pronounced, unwanted androgenic side effects. Oil skin, acne and body/facial hair growth can be seen very quickly with this drug. Many individuals respond with severe acne, often requiring medication to keep it under control. Some of these individuals find that Accutaine works well, which is a strong prescription drug that acts on the sebaceous glands to reduce the release of oils. Those with a predisposition for male pattern baldness may want to stay away from Anadrol 5007 completely, as this is certainly a possible side effect during therapy. And while some very adventurous female athletes do experiment with this compound, it is much too androgenic to recommend. Irreversible virilization symptoms can be the result and may occur very quickly, possibly before you have a chance to take action.
It is interesting to note that Anadrol 50® does exhibit some tendency to convert to dihydrotestosterone, although this does not occur via the 5-alpha reductase enzyme (responsible for altering testosterone to form DHT) as it is already a dihydrotestosterone based steroid. Aside from the added c-17 alpha alkylation (discussed below), oxymetholone differs from DHT only by the addition of a 2-hydroxymethylene group. This grouping can be removed metabolically however, reducing oxymetholone to the potent androgen l7alpha-methyl dihydrotestosterone (mesterolone; methyldihydrotestosterone)~. There is little doubt that this biotransformation contributes at least at some level to the androgenic nature of this steroid, especially when we note that in its initial state Anadrol 50® has a notably low binding affinity for the androgen receptor. So although we have the option of using the reductase inhibitor finasteride (see: Proscar®) to reduce the androgenic nature of testosterone, it offers us no benefit with Anadrol 50® as this enzyme is not involved.
The principle drawback to Anadrol 50® is that it is a 17aipha alkylated compound. Although this design gives it the ability to withstand oral administration, it can be very stressful to the liver. Anadrol 50® is particularly dubious because we require such a high milligram amount per dosage. The difference is great when comparing it to other oral steroids like Dianabol or Winstrol®, which have the same chemical alteration. Since they have a slightly higher affinity for the androgen receptor, they are effective in much smaller doses (seen in the 5mg and 2mg tablet strengths). Anadrol 50C~ has a lower affinity, which may be why we have a 50mg tablet dosage. For comparison, taking three tablets of Anadrol 50® (150mg) is roughly the equivalent of 30 Dianabol tablets or 75 Winstrol® tablets(!). When looking at the medical requirements, the recommended dosage for all ages has been 1 - 5 mg/kg of body weight. This would give a 2201b person a dosage as high as 10 Anadrol 50® tablets (500mg) per day. There should be little wonder why when liver cancer has been linked to steroid use, Anadrol 50~ is generally the culprit. Athletes actually never need such a high dosage and will take in the range of only 1-3 tablets per day. Many happily find that one tablet is all they need for exceptional results, and avoid higher amounts. Cautious users will also limit the intake of this compound to no longer than 4-6 weeks and have their liver enzymes checked regularly with a doctor. Kidney functions may also need to be looked after during longer use, as water retention/high blood pressure can take a toll on the body. Before starting a cycle, one should know to give Anadrol 50® the respect it is due. It is a very powerful drug, but not always a friendly one.
When discontinuing Anadrol 50®, the crash can be equally powerful. To begin with, the level of water retention will quickly diminish, dropping the user's body weight dramatically. This should be expected, and not of much concern. What is of great concern is restoring endogenous testosterone production. Anadrol 50® will quickly and effectively lower natural levels during a cycle, so HCG and/or Clomid®/Nolvadex ® are a must when discontinuing a cycle.
The common practice of slowly tapering off your pill dosage is wholly ineffective at raising testosterone levels. Without ancillary drugs, a run away cortisol level will likely strip much of the muscle that was gained during the cycle. If HCG and/or Clomid®/Nolvadex® are used properly, the person should be able to maintain a considerable amount of new muscle mass. Before going off, some alternately choose to first switch over to a milder injectable like Deca-Durabolin®. This is in an effort to harden up the new mass, and can prove to be an effective practice. Although a drop of weight due to water loss is likely when making the switch, the end result should be the retention of more (quality) muscle mass with a less pronounced crash. Remember ancillaries though, as testosterone production will not be rebounding during Deca therapy.
Description Anapolon ® (Oxymetholone) 50mg 20tabs, Abdi Ibrahim, Turkey:
by Bill Roberts - Like methandrostenolone (Dianabol) , oxymetholone does not bind well to the androgen receptor (AR), and most of the anabolism it provides is via non-AR-mediated effects. It is therefore a Class II steroid and is best stacked with a Class I steroid. The drug appears to give the same benefits as Dianabol. Unlike Dianabol, however, it seems that oxymetholone is progestagenic. It has been observed to cause nipple soreness or to aggravate gynecomastia even in the presence of high dose antiestrogens, strongly suggesting that the effect is not estrogenic. That effect can be reduced by concurrent use of stanozolol (Winstrol) , which is anti-progestagenic. This progestagenic effect of oxymetholone is only a concern when using aromatizing steroids. With androgens such as Primobolan , oxymetholone stacks very nicely and is a surprisingly friendly drug. In contrast, with testosterone it is a very harsh drug.
Oxymetholone does not convert to estrogen, and thus antiestrogens are not required if no aromatizable AAS are being used. However, in concert with aromatizing drugs, oxymetholone is notorious for worsening "estrogenic" symptoms, possibly by producing progestagenic symptoms which the bodybuilder confuses as estrogenic, or by altering estrogen metabolism, or by upregulating aromatase.
Compared to what bodybuilders expect of it, the drug is reasonably mild when no aromatizing steroids are present. I consider its potency approximately comparable to Dianabol . It is not unusual for a first time user to do quite well on an oxymetholone-only cycle, but more advanced users will want to stack with another steroid. Typical use is 50-150 mg/day, which should be divided into several doses per day.
Because oxymetholone is 17-alkylated, it is stressful to the liver. It is better to limit use to no more than 6 weeks or preferably four weeks before taking a break of at least equal length. Many users feel that it is more effectively used in the beginning parts of the cycle, rather than in the last few weeks.
Original Anapolon from turkey, we have reciepts from pharmacy to prove authenticity
Anapolon (ANADROL) is the strongest and at the same time also the most effective oral steroid. The compound has an extremely high androgenic effect which goes hand in hand with an extremely intense anabolic component. For this reason, dramatic gains in strength and muscle mass can be achieved in a very short time. An increase in body weight of 10-15 pounds or more in only 14 days is not unusual. Water retention is considerable, so that the muscle diameter quickly increases and the user gets a massive appearance within record time. Since the muscle cell draws a lot of water, the entire muscle system of most athletes looks smooth, in part even puffy. Anapolon does not cause a qualitative muscle gain but rather a quantitative one which in the off-season is quite welcome. Anapolon "lubricates" the joints since water is stored there as well. On the one hand this is a factor in the enormous increase of strength and on the other hand, it allows athletes with joint problems a painless workout. Powerlifters in the higher weight classes are sold on Anapolon. A strict diet together with the simultaneous intake of Nolvadex and Proviron, can significantly reduce water retention so that a distinct increase in the solid muscles is possible. By taking Anapolon the athlete experiences an enormous "pump effect" during the workout in the exercised muscles. The blood volume in the body is significantly elevated causing a higher blood supply to the muscles during workout. Anapolon increases the number of red blood cells, allowing the muscle to absorb more oxygen. The muscle thus has a higher endurance and performance level. Consequently, the athlete can rely on great power and high strength even after several sets. Some bodybuilders report such an enormous and in part painful "pump" that they end their workout after only a few sets or work on another muscle. The often-mentioned "steroid pump" manifests itself to an extreme by the intake of Anapolon and during workout it gives the athlete a fantastic and satisfying sensation. The highly androgenic effect of Anapolon stimulates the regeneration of the body so that the often-feared "over training" is unlikely. The athlete often feels that only hours after a strenuous workout he is ready for more. Even if he works out six days a week he makes continued progress. Although Anapolon is not a steroid used in preparation for a competition, it does help more than any other steroid during dieting to maintain the muscle mass and to allow an intense workout. Many bodybuilders therefore use it up to about one week before.". competition, solving the problem of water retention by taking anti estrogens and diuretics so that they will appear bulky and hard when in the limelight. As for the dosage, opinions differ. The manufacturer of the former Spanish Oxitosona 50 tablets, Syntex Latino, recommends a daily dosage of 0,5 - 2,5 mg per pounds of body weight. A bodybuilder weighing 200 pounds could therefore take up to 500 mg per day which corresponds to 10 tablets. These indications, however, are completely unrealistic, much too high, and could cause severe side effects. A dosage sufficient for any athlete would be 0,5 - 0,8 mg per pound of body weight/day. This corresponds to 1-4 tablets; i.e. 50-200 mg/day. Under no circumstances should an athlete take more than four tablets in any given day. We are of the opinion that a daily intake of three tablets should not be exceeded. Those of you who would like to try Anapolon for the first time should begin with an intake of only one 50 mg tablet. After a few days or even better, after one week, the daily dosage can be increased to two tablets, one tablet each in the morning and evening, taken with meals. Athletes who are more advanced or weigh more than 220 pounds can increase the dosage to 150 mg/day in the third week. This dosage, however, should not be taken for periods longer than two to three weeks. Following, the dose should be reduced by one tablet every week. Since Androlic-50 quickly saturates the receptors, its intake should not exceed six weeks. The dramatic mass build up which often occurs shortly after administration rapidly decreases, so that either the dosage must be increased (which the athlete should avoid due to the considerable side effects) or, even better, another product should be used. Those who take Anapolon for more than 5-6 weeks should be able to gain 20 - 25 pounds. These should be satisfying results and thus encourage the athlete to discontinue using the compound. After discontinuing Androlic-50, it is important to continue steroid treatment with another compound since, otherwise, a drastic reduction takes place and the user, as is often observed, within a short period looks the same as before the treatment. No other anabolic/androgenic steroid causes such a fast and drastic loss in strength and mass as does Anapolon. Athletes should continue their treatment with injectable testosterone such as Sustanon 250 or Testosterone enanthate for several weeks. Bodybuilders often combine Anapolon with Deca-Durabolin or Testosterone to build up strength and mass. A very effective stack which is also favored by professionals consists of Anapolon 100 mg+/day, Parabolon 228 mg+/week, and Sustanon 500 mg+/week. This stack quickly improves strength and mass but it is not suitable for and steroid novices. Anapolon is not a steroid for novices and should only be used after the athlete has achieved a certain development or has had experience with various "weaker" compounds. Stories that the elite bodybuilder uses 8-10 or more Anapolon tablets daily belongs to the realm of fairy tales. It is rare that any ambitous competing bodybuilder can do without the support of 50 mg Oxymetholon tablets; however, taking 8, 10 or 12 tablets daily is more than the organism can handle. Androlic-50 is to be taken seriously and the prevailing bodybuilder mentality "more is better" is out of place. Androlic-50 is unfortunately also the most harmful oral steroid. Its intake can cause many considerable side effects. Since it is 17-alpha alkylated it is very liver-toxic. Most users can expect certain pathological changes in their liver values after approximately few week. The compound oxymetholone easily converts into estrogen. This causes signs of feminization (e.g. gynecomastia) and water retention which in turn requires the intake of anti estrogens (e.g. Tamoxifen and Proviron) and an increased use of diuretics (e.g. Lasix) before a competition. Bodybuilders who experience a severe steroid acne caused by Androlic-50 can get this problem under control by using the prescription drug Accutane. Other possible side effects may include headaches, nausea, vomiting, stomach aches, lack of appetite, insomnia, and diarrhea. The athlete can expect a feeling of "general indisposition" with the intake of Androlic-50 which is completely in contrast to Dianabol which conveys a "sense of well-being". This often creates a paradoxical situation since the athlete continues to become stronger and bulkier while, at the same time, he does not feel well. The increased aggressiveness is caused by the resulting high level of androgen and occurs mostly when large quantities of testosterone are "shot" simultaneously with the Anapolon. Anapolon is not a steroid for older athletes since they react more sensitively to possible side effects, and the risk of liver damage and prostate cancer increases. Since the drug is usually taken with a diet rich in calories and fat needed to build up mass, the cholesterol level and the LDL values might increase while the HDL values decrease. The body's own production of testosterone is considerably reduced since Anapolon has an inhibiting effect on the hypothalamus, which in turn completely reduces or stops the release of GnRH (gonadotropin releasing hormone). For this reason the intake of testosterone-stimulating compounds such as HCG and Clomid (see relative characteristics) is absolutely necessary to maintain the hormone production in the testes. Androlic-50 is not recommended for women since it causes many and, in part, irreversible virilizing symptoms such as acne, clitorial hypertrophy, deep voice, increased hair growth on the legs, beard growth, missed periods, increased -libido, and hair loss. Androlic-50 is simply too strong for the female organism and accordingly, it is poorly tolerated. Some national and international competing female athletes, however, do take Anapolon during their "mass building phase" and achieve enormous progress. Women who do not want to give up the distinct performance-enhancing effect of Anapolon but, at the same time, would like to reduce possible side effects caused by androgen, could consider taking half a tablet (25 mg) every two days, combined with a "mild" injectable anabolic steroid such as Primobolan Depot or Durabolin. Ultimately, the use of Anapolon and its dosage are an expression of the female athlete's personal willingness to take risks. In schools of medicine Anapolon is used in the treatment of bone marrow disorders and anemia with abnormal blood formation
Anapolon is the U.S. brand name for oxymetholone. Anapolon it is a very potent oral androgen. Anapolon was first made available in 1960, by the international drug firm Syntex. Since oxymetholone is quite reliable in its ability to increase red blood cell production (and effect admittedly characteristic of nearly all anabolic/androgenic steroids), showed particular promise in treating cases of severe anemia. For this purpose it turned out to be well suited, and Anapolon was popular for quite some time.
Anapolon side effects
Many have speculated as to what makes Anapolon so troublesome in terms of estrogenic side effects. Some have suggested that it has progestational activity, similar to nandrolone, and Anapolon is not actually estrogenic at all. Since the obvious Anapolon side effects of both estrogens and progestins are very similar, this explanation might be a plausible one. However we do find medical studies looking at this possibility. Anapolon (Oxymetholone) is also a very potent androgen. This trait tends of Anapolon to produce many pronounced, unwanted androgenic side effects.
Anapolon is particularly dubious because we require such a high milligram amount per dosage of Anadrol. The difference is great when comparing it to other oral steroids like Dianabol or Winstrol, which have the same chemical alteration. Since they have a slightly higher affinity for the androgen receptor, they are effective in much smaller doses (seen in the 5mg and 2mg tablet strengths). Anapolon has a lower affinity, which may be why we have a 50mg Anadrol tablet dosage. For comparison, taking three tablets of Anapolon (150mg) is roughly the equivalent of 30 Dianabol tablets or 75 WinstroK tablets. When looking at the medical requirements, the recommended dosage for all ages has been 1 - 5 mg/kg of body weight. This would give a 220 lb person a dosage as high as 10 Anadrol tablets (500mg) per day.
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