Substance: Human Growth Hormone
Manufacturer: China, GenSci
In the human body growth hormone is produced by the pituitary gland. It exists at especially high levels during adolescence when it promotes the growth of tissues, protein deposition and the breakdown of subcutaneous fat stores. Upon maturation endogenous levels of GH decrease, but remain present in the body at a substantially lower level. In the body the actual structure of growth hormone is a sequence of 191 amino acids. Once scientists isolated this hormone, many became convinced it would exhibit exceptional therapeutic properties. It would be especially effective in cases of pituitary deficient dwarfism, the drug perhaps restoring much linear growth if administered during adolescence.
Appearance of the closed Jintropin® 40 IU
Inside Styrofoam for 40IU kit (10vials of JintropinĀ® 4IU)
JintropinĀ® 4IU vial & label details
The 1980's brought about the first prepared drugs containing Human Growth Hormone. The content was taken from a biological origin, the hormone being extracted from the pituitary glands of human corpses then prepared as a medical injection. This production method was short lived however, since it was linked to the spread of a rare and fatal brain disease. Today virtually all forms of HGH are synthetically manufactured. The recombinant DNA process is very intricate; using transformed e-coli bacterial or mouse cell lines to genetically produce the hormone structure. It is highly unlikely you will ever cross the old biologically active item on the black market (such as Grorm), as all such products should now be discontinued. Here in the United States two distinctly structured compounds are being manufactured for the pharmaceutical market. The item Humatrope by Eli Lilly Labs has the correct 191 amino acid sequence while Genentech's Protropin has 192. This extra amino acid slightly increases the chance for developing an antibody reaction to the growth hormone. The 191 amino acid configuration is therefore considered more reliable, although the difference is not great. Protropin is still Anabolics 2002 considered an effective product and is prescribed regularly. Outside of the U.S., the vast majority of HGH in circulation will be the correct 191 amino acid sequence so this distinction is not a great a concern.
The use of growth hormone has been increasing in popularity among athletes, due of course to the numerous benefits associated with use. To begin with, GH stimulates growth in most body tissues, primarily due to increases in cell number rather than size. This includes skeletal muscle tissue, and with the exception of eyes and brain all other body organs. The transport of amino acids is also increased, as is the rate of protein synthesis. All of these effect are actually mediated by IGF-1 (insulin-like growth factor), a highly anabolic hormone produced in the liver and other tissues in response to growth hormone (peak levels of IGF-1 are noted approximately 20 hours after HGH administration). Growth hormone itself also stimulated triglyceride hydrolysis in adipose tissue, usually producing notable fat loss during treatment. GH also increases glucose output in the liver, and induces insulin resistance by blocking the activity of this hormone in target cells. A shift is seen where fats become a more primary source of fuel, further enhancing body fat loss.
Its growth promoting effect also seems to strengthen connective tissues, cartilage and tendons. This effect should reduce the susceptibility to injury (due to heavy weight training), and increase lifting ability (strength). HGH is also a safe drug for the "piss-test". Although its use is banned by athletic committees, there is no reliable detection method. This makes clear its attraction to (among others) professional bodybuilders, strength athletes and Olympic competitors, who are able to use this drug straight through a competition. There is talk however that a reliable test for the exogenous administration of growth hormone has been developed, and is close to being implemented. Until this happens, growth hormone will remain a highly sought after drug for the tested athlete.
But the degree in which HGH actually works for an athlete has been the topic of a long running debate. Some claim it to be the holy grail of anabolics, capable of amazing things. Able to provide incredible muscle growth and unbelievable fat loss in a very short period of time. Since it is used primarily by serious competitors who can afford such an expensive drug, a great body of myth further surrounds HGH discussion (among those personally unfamiliar). Many will state with the utmost confidence that the incredible mass of the Olympian competitors each year is 100% due to the use of HGH. Others have crossed bodybuilding materials claiming it to be a complete waste of money, an ineffective anabolic and barely worthwhile for fat loss. With its high price tag, certainly an incredibly poor buy in the face of steroids. So we have a very wide variety of opinions regarding this drug, whom should we believe?
It is first important to understand why there the results obtained from this drug seem to vary so much. A logical factor in this regard would seem to be the price of this drug. Due to the elaborate manufacturing techniques used to produce it, it is extremely costly. Even a moderately dosed cycle could cost an athlete between $75-$150 per daily dosage. Most are unable or unwilling to spend so much, and instead tinker around with low dosages of the drug. Most who have used this item extensively claim it will only be effective at higher doses. Poor results would then be expected if low amounts were used, or the drug not administered daily. If you cannot commit to the full expense of an HGH cycle, you should really not be trying to use the drug. The average male athlete will usually need a dosage in the range of 5 to 10 I.U. per day to elicit the best results. On the low end perhaps 2 to 6 I.U. can be used daily, but this is still a considerable expense. Daily dosing is important, as HGH has a very short life span in the body. Peak blood concentrations are noted quickly (2 to 6 hours) after injection, and the hormone is cleared from the body with a half-life of only 20-30 minutes. Clearly it does not stick around very long, making stable blood levels difficult to maintain. The effects of this drug are also most pronounced when it is used for longer periods of time, often many months long. Some do use it for shorter periods, but generally only when looking for fat loss. For this purpose a cycle of at least four weeks would be used. This compound can be administered in both an intramuscular and subcutaneous injection. "Sub-Q" injections are particularly noted for producing a localized loss of fat, requiring the user to change injection points regularly to even out the effect. A general loss of fat seems to be the one characteristic most people agree on. It appears that the fat burning properties of this drug are more quickly apparent, and less dependent on high doses.
Other drugs also need to be used in conjunction with HGH in order to elicit the best results. Your body seems to require an increased amount of thyroid hormones, insulin and androgens while HGH levels are elevated (HGH therapy in fact is shown to lower thyroid and insulin levels). To begin with, the addition of thyroid hormones will greatly increase the thermogenic effectiveness of a cycle. Taking either Cytomel® or Synthroid® (prescription versions of T-3 and T-4) would seem to make the most sense (the more powerful Cytomel® is usually preferred). Insulin as well is very welcome during a cycle, used most commonly in an anabolic routine as described in this book under the insulin heading. Aside from replacing lowered insulin levels, use of this hormone is important as it can increase receptor sensitivity to IGF-1, and reduce levels of IGF binding protein-1 allowing for more free circulating IGF-1sĀ®° (growth hormone itself also lowers IGF binding protein levelss'). Steroids as well prove very necessary for the full anabolic effect of GH to become evident. Particularly something with a notable androgenic component such as testosterone or trenbolone (if worried about estrogen) should be used. The added androgen is quite useful, as it promotes anabolism by enhancing muscle cell size (remember GH primarily effects cell number). Steroid use may also increase free IGF-1 via a lowering of IGF binding proteins8z. The combination of all of these (HGH, anabolics, insulin and T-3) proves to be the most synergistic combination, providing clearly amplified results. it is of course important to note that thyroid and insulin are particularly powerful drugs that involve a number of additional risks.
Release and action of GH and IGF-1: GHRH (growth hormone releasing hormone) and SST (somatostatin) are released by the hypothalamus to stimulate or inhibit the output of GH by the pituitary. GH has direct effects on many tissues, as well as indirect effects via the production of IGF-1. IGF-1 also causes negative feedback inhibition at the pituitary and hypothalamus. Heightened release of somatostatin affects not only the release of GH, but insulin and thyroid hormones as well.
HGH itself does carry with it some of its own risks. The most predominantly discussed side effect would be acromegaly, or a noticeable thickening of the bones (notably the feet, forehead, hands, jaw and elbows). The drug can also enlarge vital organs such as the heart and kidney, and has been linked to hypoglycemia and diabetes (presumably due to its ability to induce insulin resistance). Theoretically, overuse of this hormone can bring about a number of conditions, some life threatening. Such problems however are extremely rare. Among the many athletes using growth hormone, we have very few documented cases of a serious problem developing. When used periodically at a moderate dosage, the athlete should have little cause for worry. Of course if there are any noticeable changes in bone structure, skin texture or normal health and well being during use, HGH therapy should be completely halted.
In summary, the biggest mistake we can make with this drug is to get confused by the price tag. Even a relatively short cycle of this drug (and ancillaries) will cost in the thousand(s), not hundreds of dollars. We cannot jump to the conclusion that GH is therefore the most unbelievable anabolic. This hormone is simply very complex, and costly to manufacture (though it should be getting cheaper). If you were looking to achieve just a great mass gain the $3,000 would be better spent on steroids. Growth Hormone will not turn you into an overnight "freaky" monster and it is certainly not "the answer". Yes, it is a very effective performance enhancement tool. But it is more a tool for the competitive athlete looking for more than steroids alone can provide. There is little doubt that GH contributes considerably to the physiques and performance of many top bodybuilders and athletes. In this arena, the money spent on it is well justified, the drug obviously necessary. But outside of competitive sports it is usually not.
Somatropin (rDNA origin - nonrefrigerated)
Generic Name: somatropin (rdna origin - nonrefrigerated) (SOE-ma-TROE-pin)
What Are the Health Benefits of JintropinĀ® ?
JintropinĀ® is a supplement containing human growth hormone that many athletes take in hopes of enhancing strength, agility and exercise performance. Other people take JintropinĀ® believing it can turn back the clock and forestall the aging process. However, with clinical results mixed and many potential side effects as well as legal considerations, supplements like JintropinĀ® are generally only recommended for a few special medical conditions. Exercise caution if considering using this supplement.
JintropinĀ® was developed by Chinese scientist Dr. Lei Jin, who named it after himself. It was created using recombinant DNA technology from a metabolic process found in E.coli bacteria and has the same amino acid sequence as native human growth hormone, or HGH, produced in the body. HGH is an important hormone secreted by the pituitary gland that stimulates the growth of muscles and bones, helps regulate metabolism and influences sexual pleasure. HGH production slows down as you age.
Although JintropinĀ® is approved for use in China, it isn't approved for sale or importation in the U.S. Dr. Lei has been cited by the Food and Drug Administration for the sale and trafficking of the hormones using e-mail aliases, offshore bank accounts and a network of drug traffickers to illegally distribute millions of dollars of JintropinĀ® , according to an article in the "New York Times" in September 2007. Human growth hormone is also banned for use by athletes by all professional and collegiate sport associations.
JintropinĀ® claims bodybuilders prefer the product over anabolic steroids due to its ability to promote clean muscle growth without the harmful side effects of growth from steroids. The company also claims JintropinĀ® can reduce excess body fat, particularly abdominal fat, reduce skin wrinkles and other visible effects of aging, increase bone density, strengthen the immune system and re-grow internal organs that have atrophied with age.
Growth hormone has been studied in various animal and human clinical trials, but MayoClinic.com notes there has been little in the way of results to show that HGH can help otherwise healthy adults regain their youth and vitality. However, HGH does have benefits if you have a true growth hormone deficiency unrelated to aging. This condition is rare, often caused by a pituitary tumor, and HGH helps to increase bone density, muscle mass and exercise capacity while decreasing body fat in these patients. Humane growth hormone is also approved for the treatment of muscle wasting in patients with HIV or AIDS.
A study published in "Neuroscience" in 2004 on HGH in laboratory animals over a period of four months found that the supplement helped improve age-related learning impairment and cognitive decline. Human growth hormone injections have been shown to increase muscle mass and reduce body fat in older adults, and in fact, HGH treatments like JintropinĀ® may show more results in older adults than in younger adults. Adult studies have not been long term, however, so it remains to be seen if the benefits will last or if there are additional benefits, as well as whether the side effects involved will disappear or become even worse.
If you are a healthy adult taking JintropinĀ® or another human growth hormone product, you may experience carpal tunnel syndrome, swelling in your arms and legs, joint and muscle pain or enlargement of breast tissue in men, called gynecomastia. HGH may also be a contributing factor to the development of diabetes and heart disease. Human growth hormone can lead to a condition known as acromegaly, abnormal growth of the hands and feet. HGH use in children has also been associated with a higher risk of cancer in later years.
Alternative Description JintropinĀ® 4IU(80IU/box):
- Manufactured by: GeneScience Pharmaceuticals Ltd.
- Country of origin: China
- Manufactured since: 1997 – Present
- Price: $2.1 – $4.5 per IU
Jintropin is one of the most potent recombinant Human Growth Hormones on the market today. It is a proper 191 amino acid sequence Somatropin (natural to human body) and is produced by GeneScience Pharmaceutical Co, Ltd.
According to IMS, an internationally recognized marketing firm, Jintropin is the absolute market leader in China with just over 75% of market share. It was first introduced in 1997 when it was the first somatropin brand produced in China.
Jintropin stimulates linear cell growth and increases growth rate in children who lack adequate endogenous growth hormone. In adults with growth hormone deficiency, JINTROPIN improves metabolism which in effect reduces body’s fat storage, raises energy levels, increases muscle mass, vitality and overall well-being.
Jintropin is indicated for patients suffering from severe burns, or recovering after major operation. It is given to AIDS patients to prevent muscle wasting. Children with stunted growth, caused by various illnesses will benefit from growth hormone the most.
Recreational use of growth hormone has been on the rise ever since synthetic variant first came on the 2 decades ago. Bodybuilders brought a lot of publicity to JINTROPIN as it was their favourite brand due to the low price, high quality and availability on the black market. In 2007, when actor Sylvester Stallone was caught with Jintropin by Australian customs, the media attention finally brought trouble to the manufacturer Genescience Pharmaceuticals. Chinese government temporarily revoked Gensci’s licence while charges against the CEO of the company, Mr Jin Lei were brought up in court (Providence, United States). Gensci’s operations have since returned to normal, however Jintropin disappeared from the black market to be replaced by its successor Hypertropin. Nowadays majority of Jintropin on the black market is considered to be counterfeit.
Jintropin is created using secretion technology. Genetically modified E.coli bacteria secrete human body’s identical somatropin which is then isolated and freeze dried. This method produces a very stable form of a molecule, which is otherwise too fragile to survive room temperatures or shaking. When freeze dried it remains stable at 37C (98F degrees) for over 30 days or 45C degrees for over a week.
Side effects of Jintropin
Depending on the dosage and each individual’s response to growth hormone treatment Jintropin produces typical side effects associated with high purity somatropin. These side effects range from requirement to take afternoon “baby” naps, carpal tunnel syndrome, water retention, morning aches and hypoglycemia.
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